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KMID : 0617219980090010095
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Duksung Bulletin Phamaceutical Sciences
1998 Volume.9 No. 1 p.95 ~ p.99
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Effects of Crystal Forms on Dissolution of Cephradin
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Abstract
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Five polymorphic modifications of Cephradin were prepared by recrystallization from organic solvents. The isolated crystal forms were characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and X-ray crystallography powder diffractometry. Modification 1 was the most stable form and decomposed at 201.3℃. Modification 3 and 4 were metastable. The dissolution of modification 3 and 4 was faster than that of marketed form.
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